Seminars

Subcategories

Across species, there is increasing evidence that the experiences of mothers and fathers can have an impact on subsequent generations of offspring. In this seminar, I will discuss the role of epigenetics in furthering our understanding of these parental effects and the critical role of parental influences on brain development.

Starts Mon, Dec 09, 2013 12:00 pm
Ends Mon, Dec 09, 2013 1:00 pm
Location Life Sciences Building Auditorium

Mantle Cell Lymphoma (MCL) is a rare disease, representing 2-7% of all non-Hodgkin's lymphomas in the Western world. To date, it remains incurable despite initial response to therapy. A novel therapeutic treatment has been used by Weill Cornell clinicians and is used in an ongoing clinical trial (in this particular case, N=1).

Starts Fri, Dec 06, 2013 1:00 pm
Ends Fri, Dec 06, 2013 2:00 pm
Location Life Sciences Building Auditorium

I will discuss two topics. The first is mitotic checkpoint signaling, taking advantage of a technique that we developed for rapidly recruiting checkpoint proteins to kinetochores by chemically-induced dimerization. The second is biased chromosome segregation in meiosis, also known as meiotic drive, which has fascinating implications for chromosome evolution.

Starts Mon, Nov 25, 2013 12:00 pm
Ends Mon, Nov 25, 2013 1:00 pm
Location Life Sciences Building Auditorium

Oncogenic events initiate cancer cells with different kinetics that determine initial tumor progression dynamics. We developed a quantitative model that tracks the temporal evolution of the malignant subpopulation of cancer stem cells. We discuss evolution of the most aggressive set of cancer stem cell kinetics that drives tumors into malignancy regardless of their founding properties, and propose potential treatment targets to dwarf tumor growth.

Starts Mon, Nov 11, 2013 12:00 pm
Ends Mon, Nov 11, 2013 1:00 pm
Location Life Sciences Building Auditorium

Repair of DNA breaks with the appropriate chromosomal template is critical to maintain genomic integrity and to promote proper chromosome segregation during meiosis, the specialized cell division that generates sperm and eggs. My talk will focus on how meiotic chromosome structures both control and respond to particular DNA repair outcomes.

Starts Mon, Oct 28, 2013 12:00 pm
Ends Mon, Oct 28, 2013 1:00 pm
Location Life Sciences Building Auditorium