Seminars

Subcategories

Dr. Andrew Brooks

RUCDR Infinite Biologics

Topic: RUCDR Services

Starts Mon, Oct 14, 2013 12:00 pm
Ends Mon, Oct 14, 2013 1:00 pm

Current advances in next-generation based sequencing of human cancer and molecularly targeted therapy will be presented. Early results from a genomic-sequencing trial of rare/poor prognosis cancers at CINJ will be used to highlight the promise and challenges of applying genomic profiling to the clinic.

Starts Mon, Sep 30, 2013 12:00 pm
Ends Mon, Sep 30, 2013 1:00 pm
Location Life Sciences Building Auditorium

Deciphering the role of the histone variant macroH2A in Breast Cancer progression and iPS reprogramming

Starts Mon, Sep 16, 2013 12:00 pm
Ends Mon, Sep 16, 2013 1:00 pm
Location Life Sciences Building Auditorium

Dr. Jason Spence

Starts Mon, Jun 17, 2013 12:00 pm
Ends Mon, Jun 17, 2013 1:00 pm
Location Life Sciences Building Auditorium

My lab focuses on human genetics and gene regulation. We study individual variation in gene expression, and use this variation to understand gene regulation. In this talk, I will discuss two projects. In the first part, I will describe the regulation of a histone demethylase, KDM4C, and show how individual differences in KDM4C expression affect its enzymatic activity and impact normal and cancer cell growth. In the second part, I will describe the discovery of RNA sequences that differ from their corresponding DNA sequences in human cells. These include known RNA editing sites and unknown events such as purine to pyrimidine transversions. I will describe the role of ADAR proteins in mediating some of these events, and our findings of when during transcription these RNA-DNA differences are formed. Overall, I will discuss the lessons we learned from studying natural variation in human gene expression, and the significance of our findings on basic understanding of gene regulation and disease manifestations.

Starts Mon, Jun 10, 2013 12:00 pm
Ends Mon, Jun 10, 2013 1:00 pm
Location Life Sciences Building Auditorium