Neurons Put Out the Trash: A Novel Facet of Proteostasis and Mitochondrial Quality Control

When

Mon, Nov 18, 2019 12:00 pmuntilMon, Nov 18, 2019 1:00 pm

Where

Life Sciences Building Auditorium
145 Bevier Road
Piscataway
NJ
08854

Contact

(732) 445-1027 x 52563

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About

Monica Driscoll, Ph.D.
Distinguished Professor
Molecular Biology & Biochemistry
Rutgers University

Protein aggregation and mitochondrial dysfunction are critical problems in aging and neurodegenerative disease. Confounding the problem, aggregates and mitochondria can spread to neighboring cells, which can impair function of the receiving cell and promote disease spread. We found that C. elegans neurons can collect and hand off trash to neighboring cells and I will present our work on the dissection of the trash extrusion mechanism, which we speculate might be analogous to mechanisms of transfer operative in human brain.