Progress in understanding the genetic architecture of Tourette Disorder and other chronic tic disorders


Mon, Sep 13, 2021 4:00 pmuntilMon, Sep 13, 2021 5:00 pm


Zoom- Virtual Seminar
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Gary Heiman, Ph.D.
Associate Professor
Department of Genetics
Rutgers University
Piscataway, NJ

Tourette’s Disorder (TD) and other chronic tic disorders (CTDs) are developmental neuropsychiatric disorders characterized by chronic motor and/or phonic tics that make their appearance before 18 years of age. Family studies consistently show that TD strongly aggregates within families and that other CTDs are biologically sufficiently related that genetic studies often combine them into a category of “any CTD” rather than analyzing them separately. Heritability studies clearly indicate a strong genetic contribution to the etiology of CTDs. Empiric recurrence risk estimate of CTDs in first-degree relatives is estimated at ~30%. It is commonly accepted that CTDs are the result of complex and heterogeneous inheritance involving both common and rare variants, which are likely interacting with environmental factors (e.g., pre- and perinatal complications). Over and above their psychosocial sequelae such as stigma or bullying, CTDs can severely impact quality of life because of a high comorbidity rate with other neuropsychiatric disorders including obsessive–compulsive disorder (OCD, ~50%) and attention-deficit/hyperactivity disorder (ADHD, ~54%). Individuals with CTDs have substantial risk for dying by and attempting suicide, independent of having other psychiatric comorbidities.

In this talk, I will review the recent progress in understanding the genetic architecture of CTDs. I will focus on recent findings from Tourette International Collaborative Genetics (TIC Genetics) group, an international effort to further our understanding of the genetic architecture of these disorders.

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| Meeting ID: 986 4197 9928 |Passcode: Genetics 

Host: Department of Genetics
Phone: 848-445-1638