The Midbody is a Translationally Active RNP Granule


Mon, Sep 16, 2019 12:00 pmuntilMon, Sep 16, 2019 1:00 pm


Life Sciences Building Auditorium
145 Bevier Road


(732) 445-1639

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Ahna Skop, Ph.D.
Department of Genetics
University of Wisconsin-Madison
Madison, WI

The midbody is a transient structure derived from the spindle midzone and is essential for normal cell division. Long conceptualized as a simple structural remnant subject to degradation following cytokinesis, emerging data suggest that midbodies may play instructive post-mitotic roles in establishing cell fate, tissue polarity, cilia formation, neuron function, and oncogenesis.  We are exploring the hypothesis that the electron-dense midbody matrix, functions as a novel class of RNA granule, and thus, we are calling this structure the Cytokinesis granule (or Cgranule).  We are currently assessing the functional significance of specific C-granule RNAs, signals controlling RNA localization, RNP formation and maintenance, and the mechanism of localized translation. We suggest that one of the goals of animal cytokinesis, besides cell separation, is to assemble the C-granule, a structure utilized primarily post-mitotically in cell fate and proliferation decisions.