Human Genetics Institute of New Jersey

I have been creating an in vitro model for HIV infection of the central nervous system (CNS) using stem cell derived microglia-containing cerebral organoids. The objective is to develop a human brain organoid model to better understand Human Immunodeficiency Virus (HIV-1) infection of the CNS and elucidate how virus-host interactions contribute to neuropathology. I use human pluripotent stem cells differentiated into microglia precursors and Neural Progenitor Cells (NPCs) that are combined to form organoids.An HIV-organoid model presents a unique in vitro platform for investigating the consequence of HIV infection on the neural microenvironment, virus-host interactions at large, and how these lead to functional alterations in human neurons.

I also participate in research relating to our RUCDR-generated patient derived stem cell lines for a Mu Opioid Receptor polymorphism implicated in addiction. We are examining whether ethanol has differential effects between lines with and without the polymorphism. 

I completed my undergraduate here at Rutgers and majored in Genetics. I am interested in the genetic basis of neuropathology and how diverse genetic backgrounds influence treatment responses.