Dr Loren Runnels

The focus of our laboratory research is to elucidate the function and the regulation of the TRPM7 and TRPM6 ion channels. Our lab had demonstrated a critical role for these ion channels in gastrulation and neural tube closure during early embryonic development. The focus of our current work is to determine the function of these ion channels in renal magnesium homeostasis, cardiac fibrosis, neuronal cell death during stroke, and cancer.