Interests
My primary research goal is to use pluripotent stem cells as models of human development and disease, particularly of the nervous system. I am currently generating induced pluripotent stem cells (iPSC) from various subject tissues, including blood. Once generated these iPSC are being directed to differentiate into neural lineages where we then use these cells to understand the basic signalling pathways guiding developmentMy secondary research goal is to understand the role the cell cycle plays in the differentiation of pluripotent stem cells. In particular how a pluripotent cells makes the transition from an undifferentiated, dividing cell to a differentiated, senescent cell.
Research Support
5/20135/2018Center for Genomic Studies on Mental DisordersNational Institute of Mental HealthU24MH068457-11Jay TischfieldCollaborator
7/20086/2016Simons Simplex Collection Cell and DNA RepositorySimons FoundationN/AJay TischfieldCollaborator
4/20133/2015Developing an in vitro neurocircuitry model of addiction using risk-associated human neuronsNational Institute of Drug AddictionR21 DA035594-01Zhiping PangCollaborator
4/20133/2015Neurons from blood-derived stem cells as a model of A-T neurodegenerationA-T Children%u2019s ProjectN/ARon HartCollaborator