My primary research goal is to use pluripotent stem cells as models of human development and disease, particularly of the nervous system. I am currently generating induced pluripotent stem cells (iPSC) from various subject tissues, including blood. Once generated these iPSC are being directed to differentiate into neural lineages where we then use these cells to understand the basic signalling pathways guiding developmentMy secondary research goal is to understand the role the cell cycle plays in the differentiation of pluripotent stem cells. In particular how a pluripotent cells makes the transition from an undifferentiated, dividing cell to a differentiated, senescent cell.
- "Center for Genomic Studies on Mental Disorders" National Institute of Mental Health (U24MH068457-11) Jay Tischfield Collaborator
- "Simons Simplex Collection Cell and DNA Repository" Simons Foundation Jay Tischfield Collaborator
- "Developing an in vitro neurocircuitry model of addiction using risk-associated human neurons" National Institute of Drug Addiction (R21 DA035594-01) Zhiping Pang Collaborator
- "Neurons from blood-derived stem cells as a model of A-T neurodegeneration" A-T Children u2019s Project Ron Hart Collaborator